Author:
Boreham CJ,Broomhead JA,Fairlie DP
Abstract
195Pt and 15N n.m.r, spectra for aqueous
solutions of the anti-cancer drug cis-diamminedichloroplatinum(II)
and its hydrolysis and oligomerization products are reported. In the blood
substituteHanks medium, conversion of
cis-[Pt(15NH3)2(H20)2](NO3)2
into cis[PtCl2(15NH3)2],
cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+
and [Pt(15NH3)2OH]22+
has been observed, the reaction taking several hours at 30�C. In 0.15 M sodium
chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+
are converted overnight into cis-[PtCl(H2O)(NH3)2]+.
The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4
and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3
have been reassigned to Pt-N modes.
Cited by
149 articles.
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