Abstract
SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
30 articles.
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