Candida biofilm formation and recurrent vulvovaginal candidiasis

Abstract

Recurrent vulvovaginal candidiasis (RVVC), a recalcitrant Candida infection of the lower female reproductive tract, is a difficult-to-treat medical condition affecting the morbidity of many otherwise healthy women. Cumulative experimental evidence supports the involvement of biofilm formation of Candida in the pathogenesis of RVVC and its treatment failure. In this review, we will discuss important insights into the roles of Candida biofilms in RVVC.