Author:
Cambie RC,Grigor BA,Hayward RC,Nielson AJ
Abstract
Methods for isomerization
of the 12-methoxy-19-norpodocarpatetraene mixture obtained from oxidative
decarboxylation of 12-methoxypodocarpa-8,11,13-trien-19-oic acid (1) with lead
tetraacetate have been examined. Acid-catalysed isomerization gives a mixture
of the endocyclic isomers (11) and (19) while
iodine-catalysed isomerization gives a mixture enriched in the isomer (19) to
the extent of 80%. Metal-catalysed decarbonylation of
the acid chloride (6) and oxidative decarboxylation of the acetoxy acid (7) have
also been examined.
Cited by
11 articles.
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