Abstract
In a new approach to the synthesis of wedeligenin , an A/B-ring intermediate (13a) has been synthesized. The β- keto ester (15) was readily prepared from Wieland-Meischer ketone in three steps. Baeyer-Villiger oxidation of (15) and subsequent methylenation provided an alkene (16) which contained the malonyl substituent, later to become the gem-diester of (13a). Regiospecific conversion of the alkene into a bromohydrin followed by cyclization afforded (13a). This provided an A/B-ring intermediate which could be further elaborated to allow C/D-ring annulation.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献