Author:
Bagnell L,Jeffery EA,Meisters A,Mole T
Abstract
Nickel acetylacetonate
catalyses the methylation of nitriles by trimethylaluminium. Methylation occurs
in hydrocarbon solvent at near ambient temperature to give, upon hydrolysis,
acetyl compounds (RCN → RCOMe). The following nitriles have been
converted into acetyl compounds in moderate to good yields: benzonitrile,
dodecyl cyanide, benzyl cyanide, diphenylacetonitrile, p-chlorobenzo-nitrile
and glutaronitrile. Side reactions of the ketenimide formation-and- condensation
type appear to occur less than with methyllithium and methyl Grignard reagents.
Cited by
31 articles.
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