Structural Studies of N-Acyl 1,1′-Bis(1,2,3,4-tetrahydroisoquinoline) Derivatives

Abstract

The X-ray crystal structures of N-acyl substituted 1,1′-bis(1,2,3,4-tetrahydroisoquinolines) are disclosed for the first time and evidence is provided that the molecules reside in single preferred conformations in solution and solid states, with axial bonds bridging C1–C1′ that have no steric impediment to rotational freedom.