Clinical characteristics of patients with coronary atherosclerosis depending on blood fatty acids

Abstract

Aim. To examine the differences in clinical parameters in patients with coronary atherosclerosis based on fatty acid profile.Methods.60 men with angiographically verified atherosclerosis of the coronary arteries underwent the analysis of fatty acids followed by coronary endarterectomy. Patients were divided into two groups after histological analysis of the intimamedia fragments. Men without unstable plaques in the coronary arteries were included in Group 1, whereas patients with unstable atherosclerotic plaques were included in Group 2. Blood serum levels of fatty acids were measured by highefficiency gas-liquid chromatography.Results.The predicted probability value and the predicted group membership in men with coronary atherosclerosis were calculated using the logistic regression. The following clinical patterns in men with unstable atherosclerotic plaques included increased prevalence of myocardial infarction with the event over 10 years ago, severe angina pectoris (III and IV functional class) and chronic heart failure, in comparison with CAD patients without unstable plaques.Conclusion. Fatty acid profile was associated with altered individual history of coronary atherosclerosis.