ASSOCIATION OF POLYMORPHISM OF PLATELET RECEPTOR GENES GPIA (C807T), GPIIIA (T1565C) ON PLATELET ACTIVITY AND EFFICIENCY OF ACETYLSALICYLIC ACID IN PATIENTS WITH STABLE ANGINA

Abstract

Background. Recently, much attention has been paid to the genetic aspects of thrombus formation. Understanding the genetic contribution to platelet function may have clinical implications for personalized pharmacotherapy. The aim of the study was to assess the distribution of polymorphic variants C807T of the ITGA2 gene and T1565C of the ITGB3 gene and to study their effect on platelet activity and acetylsalicylic acid (ASA) efficiency in patients with stable angina (SA) living in the Grodno region. Material and methods. The study included 92 patients with SA, 89 of them underwent elective percutaneous coronary intervention (PCI), and 93 were apparently healthy people. The survey data (general clinical, aggregometry, general blood count and platelet indices, polymerase chain reaction genotyping) were analyzed using the STATISTICA 10.0 program. Results. The prevalence of carriage of genotypes associated with possible variability of response to ASA therapy among patients with SA was 69.6% for the C807T polymorphic locus of the ITGA2 gene, 31.5% for the T1565C polymorphic ITGB3 locus, 60.2% and 37.6% among practically healthy individuals respectively. A lower frequency of the CC variant of the C807T polymorphic locus of the ITGA2 gene was noted in the group of men with SA in comparison with the control group of men (p = 0.043) according to Fisher's exact test. The patients were divided into subgroups (SG). Carriers of the CC genotype of the C807T polymorphic locus of the ITGA2 gene and TT genotype of the T1565C polymorphic locus of the ITGB3 gene were in SG1. Carriers of the CT+TT genotypes of the C807T polymorphic locus of the ITGA2 gene and TC+CC of the T1565C polymorphic locus of the ITGB3 gene were in SG2. The ASPI-test values were 23.0 [14.0; 50.5] U in SG1 and 22.5 [14.5; 34.5] U in SG2 of the ITGA2 gene, p>0.05. The ASPI-test values were 23.0 [16.0; 38.0] U in SG1 and 20.0 [14.0; 34.0] U in SG2 of the ITGB3 gene, p>0.05. Conclusions. No relationship was found between the polymorphic variants C807T of the ITGA2 gene and T1565C of the ITGB3 gene and platelet activity and the effectiveness of ASA in patients with SA.