Affiliation:
1. Rutgers Equine Science Center, Rutgers, the State University of New Jersey, 57 U.S. Highway 1, New Brunswick, NJ 08850, USA
Abstract
Inflammation-associated insulin resistance contributes to chronic disease in humans and other long-lived species, such as horses. Insulin resistance arises due to an imbalance among molecular signalling mediators in response to pro-inflammatory cytokines in the aged and obese. The mammalian heat shock protein response has received much attention as an avenue for attenuating inflammatory mediator signalling and for contributing to preservation and restoration of insulin signalling in metabolically important tissues. Data on heat shock proteins and inflammatory signalling mediators in untrained and aged horses are lacking, and horses represent an untapped resource for studying the mediator imbalance contributing to insulin resistance in a comparative model.
Publisher
Wageningen Academic Publishers
Subject
Physiology (medical),Veterinary (miscellaneous),Orthopedics and Sports Medicine,Physiology,Biochemistry,Endocrinology, Diabetes and Metabolism,Biophysics