Zearalenone and its metabolites as endocrine disrupting chemicals-Reference-Cited by-同舟云学术

Zearalenone and its metabolites as endocrine disrupting chemicals

Published:2010-11-01 Issue:4 Volume:3 Page:385-401
ISSN:1875-0710
Container-title:World Mycotoxin Journal
language:en
Short-container-title:World Mycotoxin Journal

Author:

Metzler M.¹,Pfeiffer E.¹,Hildebrand A.¹

Affiliation:

1. Chair of Food Chemistry, Institute of Applied Biosciences, Karlsruhe Institute of Technology (KIT), Bldg. 50.41, Adenauerring 20, 76131 Karlsruhe, Germany

Abstract

Zearalenone (ZEA) is a macrocyclic β-resorcylic acid lactone produced by numerous species of Fusarium. It frequently contaminates corn and cereal products in many regions of the world. The biological activity of ZEA is dominated by its pronounced oestrogenicity, which is even enhanced in certain reductive metabolites. This review updates the metabolism in fungi, plants and mammalian systems, as well as the pharmacokinetics of ZEA. The present evidence for the hormonal effects of the parent mycoestrogen and some of its metabolites in vitro and in farm and experimental animals in vivo is reviewed, together with its association with endocrine-disruptive effects in humans. Possible mechanisms of the oestrogenic and carcinogenic activity of ZEA are discussed and future areas of research proposed.

Publisher

Wageningen Academic Publishers

Subject

Public Health, Environmental and Occupational Health,Toxicology,Food Science

Link

https://www.wageningenacademic.com/doi/pdf/10.3920/WMJ2010.1244

Reference120 articles.

1. The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice

2. Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone

3. Comparative study of toxic effects of zearalenone and its two major metabolites α-zearalenol and β-zearalenol on cultured human Caco-2 cells

4. The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway

5. Long-term carcinogenicity and toxicity study of zearalenone in the rat

Cited by 153 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Increased Dissemination of Aflatoxin- and Zearalenone-Producing Aspergillus spp. and Fusarium spp. during Wet Season via Houseflies on Dairy Farms in Aguascalientes, Mexico;Toxins;2024-07-01

2. Assessment of Mycotoxin Exposure and Associated Risk in Pregnant Dutch Women: The Human Biomonitoring Approach;Toxins;2024-06-18

3. Estrogenic, androgenic, and genotoxic activities of zearalenone and deoxynivalenol in in vitro bioassays including exogenous metabolic activation;Mycotoxin Research;2024-04-08

4. Increased NAD+ levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation;Reproductive Toxicology;2024-03

5. Simultaneous Determination of Trichothecenes and Zearalenone in Food by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS);Analytical Letters;2024-01-15