Synthesis, characterization, anti-microbial activity studies of salicylic acid and 2-aminopyridine derivatives salts and their Cu(II) complexes

Abstract

Four salts (1-4) obtained between salicylic acid (H2salic) and 2-amino-Xpyridine {X = (2ap), 3-methyl (2a3mp), 4-methyl (2a4mp) and 5-methyl (2a5mp)} and the Cu(II) complex of H2salic (5) by methods available in the literature and new Cu(II) complexes (6-9) of the salts (1-4) has been prepared. The Cu(II) complexes (6-9) were suggested by elemental analysis, FT-IR, AAS, UV-Vis and magnetic susceptibility techniques. The spectroscopic research results indicated that complexes 6-9 have tetrahedral geometries. Additionally, antimicrobial activities of free ligands (H2salic, 2ap, 2a3mp, 2a4mp and 2a5mp), 1-9 were studied against Candida albicans (F89) yeast, Staphylococcus aureus (NRRL B-767), Pseudomonas aeruginosa (ATCC 27853), Bacillus subtilis, Listeria monocytogenes (ATCC 7644), Escherichia coli (ATCC25922) and Enterococcus faecalis (ATCC 29212) bacteria. The results were comparisoned with the control compounds (Fluconazole, Vancomycin, Cefepime and Levofloxacin). All compounds showed activity against bacteria and yeasts.