Clinical Use of Pediatric Bosentan in Japanese Children with Pulmonary Arterial Hypertension: Investigation of Efficacy, Pharmacokinetics, Safety, and Tolerability-Reference-Cited by-同舟云学术

Clinical Use of Pediatric Bosentan in Japanese Children with Pulmonary Arterial Hypertension: Investigation of Efficacy, Pharmacokinetics, Safety, and Tolerability

Published:2018 Issue:1 Volume:34 Page:22-29
ISSN:0911-1794
Container-title:Pediatric Cardiology and Cardiac Surgery
language:en
Short-container-title:Ped Cardiol Card Surg

Author:

Saji Tsutomu¹,Nakanishi Toshio²,Yamada Osamu³,Doi Shozaburo⁴,Ueda Hideaki⁵,Inuzuka Ryo⁶,Somura Jyunpei⁷,Dingemanse Jasper⁸,Hatta Motonori⁹,Yokoyama Yoshinari⁹

Affiliation:

1. Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University

2. Pediatric Cardiology, Tokyo Women’s Medical University

3. Department of Pediatrics, National Cerebral and Cardiovascular Center

4. Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Graduate School

5. Department of Cardiology, Kanagawa Children's Medical Center

6. Department of Pediatrics, Tokyo University

7. Department of Pediatrics, Shiga University of Medical Science

8. Clinical Pharmacology, Actelion Pharmaceuticals Ltd.

9. Research and Development, Actelion Pharmaceuticals Japan Ltd.

Publisher

The Japanese Society of Pediatric Cardiology and Cardiac Surgery

Subject

Polymers and Plastics,General Environmental Science

Link

https://www.jstage.jst.go.jp/article/jspccs/34/1/34_2017-0012/_pdf

Reference14 articles.

1. 1) D’Alonzo GE, Barst RJ, Ayres SM, et al: Survival in patients with primary pulmonary hypertension: Results from a national prospective registry. Ann Intern Med 1991; 115: 343–349

2. 2) Galiè N, Hoeper MM, Humbert M, et al: Guidelines for the diagnosis and treatment of pulmonary hypertension: The task force for the diagnosis and treatment of pulmonary hypertension of ESC and ERS, endorsed by the ISHLT. Eur Heart J 2009; 30: 2493–2537

3. 3) Sandoval J, Bauerle O, Gomez A, et al: Primary pulmonary hypertension in children: Clinical characterization and survival. J Am Coll Cardiol 1995; 25: 466–474

4. 4) Lador F, Sekarski N, Beghetti M: Treating pulmonary hypertension in pediatrics. Expert Opin Pharmacother 2015; 16: 711–726

5. 5) Barst RJ, Ivy D, Dingemanse J, et al: Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. Clin Pharmacol Ther 2003; 73: 372–382