Novel carbazole alkaloid from Murraya koenigii (l.) Spreng
Author:
MEHREEN Arifa1ORCID, KAMAL Shagufta2ORCID, MUSAYEVA Sevinc3ORCID, QAİSAR Muhammad2ORCID, URAİNAB Sumia2ORCID, ULLAH Asad4ORCID
Affiliation:
1. Department of Zoology, wildlife and fisheries, university of Agriculture, Faisalabad 2. Department of Biochemistry, Government College University, Faisalabad, Pakistan 3. Institute of Molecular Biology and Biotechnologies, Baku, Azerbaijan 4. Department of biochemistry, Okara University, Faisalabad, Pakistan
Abstract
Background: The plant Murraya koenigii (L.) Spreng.native to Pakistan and India and a part of the Rutaceae family, plays a vital role in the Indian Ayurvedic medicine system. Studies have shown that this plant's bark, roots, and leaves contain many carbazole alkaloids. These alkaloids are known to have substantial therapeutic properties.
Methods:
The crushed and powdered organs of M. koenigii were extracted with several solvents (acetone, chloroform, and methanol). Then, using column chromatography, a dull brown oily substance, MK- 1 (1.05 g), was obtained with chloroform and methanol (7:3).
Result
We have successfully isolated a new carbazole alkaloid, 3-geranyl 8-hydroxy 6, 7-di methoxy 3’, 3’-dimethyl 1, 2-pyranocarbazole, from the seeds of M. koenigii. The structure was further elucidated by cross-referencing our NMR, UV, IR, and MS data with that found in the published literature.
Conclusion:
Comparing the previously published literature data clearly explained that this alkaloid is new to M. koenigii.
Publisher
International Journal of Secondary Metabolite
Subject
Plant Science,Biochemistry,Biophysics,Biotechnology
Reference17 articles.
1. Abeysinghe, D., Alwis, D., Kumara, K., & Chandrika, U. (2021). Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review. Evidence-Based Complementary and Alternative Medicine, 2021, 1 23. https://doi.org/10.1155/2021/5523252 2. Aniqa, A., Kaur, S., & Sadwal, S. (2021). A Review of the Anti-Cancer Potential of Murraya koenigii(Curry Tree) and Its Active Constituents. Nutrition and Cancer, 74(1), 12-26. https://doi.org/10.1080/01635581.2021.1882509 3. Balakrishnan, R., Vijayraja, D., Jo, S.H., Ganesan, P., Su-Kim, I., & Choi, D.K. (2020). Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds. Antioxidants (Basel, Switzerland), 9(2), 101. https://doi.org/10.3390/antiox9020101 4. Batool, S., Khera, R., Hanif, M., Ayub, M., & Memon, S. (2020). Curry Leaf. Medicinal Plants Of South Asia, 179-190. https://doi.org/10.1016/b978-0-08-102659-5.00014-8 5. Bhattacharyya, P., & Chakraborty, D. (1987). Carbazole Alkaloids. Fortschritte Der Chemie Organischer Naturstoffe / Progress in The Chemistry of Organic Natural Products, 52, 159-209. https://doi.org/10.1007/978-3-7091-8906-1_4
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