Antioxidant and diuretic effects of flower extract of Laurus nobilis
Author:
TAHİRİ Nor El Houda1ORCID, LAGHOUİZİ Asmae2ORCID, ABOULGHAZİ Abderrazak2ORCID, SOULO Najoua2ORCID, LYOUSSİ Badiaa2ORCID, LRHORFİ Lalla Aicha2ORCID
Affiliation:
1. faculté des sciences ibn tofail 2. sidi mohamed ben abdelah university, Faculty of sciences Dhar El Mahraz
Abstract
Diuretic medications are widely used and can come with negative effects. Because they are effective and have fewer adverse effects than other treatments for renal illness, medicinal plants have become increasingly important. This study aimed to investigate the antioxidant ability and the impact of Laurus nobilis extract (flower) on diuresis in rats. Two doses of 200 mg and 400 mg of Laurus nobilis extract were used to treat rats for thirty days. Then, we assessed all changes induced in urine and plasma parameters of rats, using furosemide as a standard drug. Further, we evaluated the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant ability (DPPH and FRAP) of the tested extract. The results obtained show that the administration of a single dose of Laurus nobilis extract improved the urine flow significantly after 4 h of treatment. Similarly, both doses of the tested extract enhanced sodium, potassium, and chloride excretion without inducing hypokalemia. A similar tendency was recorded for both urine and creatinine, while the results of the furosemide group revealed a significant hypokalemia effect of the standard drug. Laurus nobilis demonstrated superior antioxidant and diuretic effects without inducing hypokalemia due to the higher content of phenolic and flavonoid content. However, more advanced studies are required to explore the constituents of Laurus nobilis extracts and essential oils, as well as to test their pertinent biological activities.
Publisher
International Journal of Secondary Metabolite
Subject
Plant Science,Biochemistry,Biophysics,Biotechnology
Reference40 articles.
1. Alarcón-Alonso, J., Zamilpa, A., Aguilar, F.A., Herrera-Ruiz, M., Tortoriello, J., & Jimenez-Ferrer, E. (2012). Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. Journal of Ethnopharmacology, 139(3), 751‑756. https://doi.org/10.1016/j.jep.2011.12.005 2. Anzano, A., de Falco, B., Grauso, L., Motti, R., & Lanzotti, V. (2022). Laurel, Laurus nobilis L. : A review of its botany, traditional uses, phytochemistry and pharmacology. Phytochemistry Reviews, 21(2), 565‑615. https://doi.org/10.1007/s11101-021-09791-z 3. Aourach, M., Barbero, G.F., González de Peredo, A.V., Diakite, A., El Boukari, M., & Essalmani, H. (2021). Composition and antifungal effects of aqueous extracts of Cymbopogon citratus , Laurus nobilis and Santolina chamaecyparissus on the growth of Fusarium oxysporum f. Sp. Lentis. Archives of Phytopathology and Plant Protection, 54(19‑20), 2141‑2159. https://doi.org/10.1080/03235408.2021.1922169 4. Batiha, G.E.-S., Beshbishy, A.M., Alkazmi, L., Adeyemi, O.S., Nadwa, E., Rashwan, E., El-Mleeh, A., & Igarashi, I. (2020). Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts. BMC Complementary Medicine and Therapies, 20(1), 87. https://doi.org/10.1186/s12906-020-2848-2 5. Bourebaba, N., Kornicka-Garbowska, K., Marycz, K., Bourebaba, L., & Kowalczuk, A. (2021). Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis – Possible implication in pharmacotherapy. Mitochondrion, 59, 190‑213. https://doi.org/10.1016/j.mito.2021.06.003
|
|