Biosynthesis of ZnO nanoparticles using Laurus nobilis leaf extract and investigation of antiproliferative and antibacterial activity potential
Author:
ÖNEM Ebru1ORCID, MERT SİVRİ Firdevs2ORCID, AKKOÇ Senem1ORCID, ÇIRRIK Cennet1ORCID, EZER Aleyna1ORCID
Affiliation:
1. SÜLEYMAN DEMİREL ÜNİVERSİTESİ 2. Süleyman Demirel University
Abstract
Nanotechnology has recently emerged as an essential field of study in modern materials science. The green synthesis of nanoparticles using plant extracts is of great interest because it is cost-effective, eco-friendly, and suitable for large-scale production. The study highlights the synthesis of ZnO nanoparticles (ZnO NPs) using Laurus nobilis (L. nobilis) leaf extract and their characterization and biological activities for potential applications in the biomedical field. ZnO NPs were synthesized using Laurus nobilis leaf extract. The synthesized ZnO NPs were characterized by UV-Vis spectroscopy, TEM, XRD, and FT-IR. According to TEM and XRD diffraction analysis, with a mean particle size of 16 ± 5 nm, it was found that the synthesized ZnO NPs contain a hexagonal wurtzite structure. ZnO NPs have antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The antiproliferative activity of ZnO NPs was tested against the human colon cancer cell line and mouse normal fibroblast cell line using MTT assay in vitro. The results show that the prepared nanoparticles had antiproliferative in screened incubation time and concentrations.
Funder
Suleyman Demirel University
Publisher
International Journal of Secondary Metabolite
Subject
Plant Science,Biochemistry,Biophysics,Biotechnology
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