Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives

Author:

Fleskes Raquel E.1,Bader Alyssa C.23,Tsosie Krystal S.45,Wagner Jennifer K.6,Claw Katrina G.7,Garrison Nanibaa’ A.8

Affiliation:

1. Department of Anthropology, University of Connecticut, Storrs, Connecticut, USA;

2. Department of Anthropology, University of Colorado Boulder, Boulder, Colorado, USA;

3. Sealaska Heritage Institute, Juneau, Alaska, USA

4. Native BioData Consortium, Eagle Butte, South Dakota, USA;

5. College of Arts and Sciences, Vanderbilt University, Nashville, Tennessee, USA

6. School of Engineering Design, Technology, and Professional Programs; Institute for Computational and Data Sciences; Department of Biomedical Engineering; and Rock Ethics Institute, Pennsylvania State University, University Park, Pennsylvania, USA;

7. Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA;

8. Institute for Society and Genetics, Institute for Precision Health, and Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, California, USA;

Abstract

Over the past two decades, the study of ancient genomes from Ancestral humans, or human paleogenomic research, has expanded rapidly in both scale and scope. Ethical discourse has subsequently emerged to address issues of social responsibility and scientific robusticity in conducting research. Here, we highlight and contextualize the primary sources of professional ethical guidance aimed at paleogenomic researchers. We describe the tension among existing guidelines, while addressing core issues such as consent, destructive research methods, and data access and management. Currently, there is a dissonance between guidelines that focus on scientific outcomes and those that hold scientists accountable to stakeholder communities,such as descendants. Thus, we provide additional tools to navigate the complexities of ancient DNA research while centering engagement with stakeholder communities in the scientific process.

Publisher

Annual Reviews

Subject

Genetics (clinical),Genetics,Molecular Biology

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