Realizing the Physics of Motile Cilia Synchronization with Driven Colloids

Author:

Bruot Nicolas1,Cicuta Pietro2

Affiliation:

1. Institut Lumière Matière, UMR5306 Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Université de Lyon, Institut Universitaire de France, 69622 Villeurbanne cedex, France;

2. Cavendish Laboratory, University of Cambridge, CB3 0HE Cambridge, United Kingdom;

Abstract

Cilia and flagella in biological systems often show large scale cooperative behaviors such as the synchronization of their beats in “metachronal waves.” These are beautiful examples of emergent dynamics in biology, and are essential for life, allowing diverse processes from the motility of eukaryotic microorganisms, to nutrient transport and clearance of pathogens from mammalian airways. How these collective states arise is not fully understood, but it is clear that individual cilia interact mechanically, and that a strong and long-ranged component of the coupling is mediated by the viscous fluid. We review here the work by ourselves and others aimed at understanding the behavior of hydrodynamically coupled systems, and particularly a set of results that have been obtained both experimentally and theoretically by studying actively driven colloidal systems. In these controlled scenarios, it is possible to selectively test aspects of living motile cilia, such as the geometrical arrangement, the effects of the driving profile and the distance to no-slip boundaries. We outline and give examples of how it is possible to link model systems to observations on living systems, which can be made on microorganisms, on cell cultures or on tissue sections. This area of research has clear clinical application in the long term, as severe pathologies are associated with compromised cilia function in humans.

Publisher

Annual Reviews

Subject

Condensed Matter Physics,General Materials Science

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