Affiliation:
1. Department of Physics and
2. Department of Chemistry, University of California, Santa Barbara, California 93106;
Abstract
Protein aggregation involves the self-assembly of normally soluble proteins into large supramolecular assemblies. The typical end product of aggregation is the amyloid fibril, an extended structure enriched in β-sheet content. The aggregation process has been linked to a number of diseases, most notably Alzheimer's disease, but fibril formation can also play a functional role in certain organisms. This review focuses on theoretical studies of the process of fibril formation, with an emphasis on the computational models and methods commonly used to tackle this problem.
Subject
Physical and Theoretical Chemistry
Cited by
152 articles.
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