Measuring and Modeling Single-Cell Heterogeneity and Fate Decision in Mouse Embryos

Author:

Fiorentino Jonathan12,Torres-Padilla Maria-Elena13,Scialdone Antonio12

Affiliation:

1. Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, D-81377 München, Germany;

2. Institute of Functional Epigenetics (IFE) and Institute of Computational Biology (ICB), Helmholtz Zentrum München, D-85764 Neuherberg, Germany

3. Faculty of Biology, Ludwig-Maximilians Universität, D-82152 Planegg-Martinsried, Germany

Abstract

Cellular heterogeneity is a property of any living system; however, its relationship with cellular fate decision remains an open question. Recent technological advances have enabled valuable insights, especially in complex systems such as the mouse embryo. In this review, we discuss recent studies that characterize cellular heterogeneity at different levels during mouse development, from the two-cell stage up to gastrulation. In addition to key experimental findings, we review mathematical modeling approaches that help researchers interpret these findings. Disentangling the role of heterogeneity in cell fate decision will likely rely on the refined integration of experiments, large-scale omics data, and mathematical modeling, complemented by the use of synthetic embryos and gastruloids as promising in vitro models.

Publisher

Annual Reviews

Subject

Genetics

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