Adjuvant Bisphosphonates and Breast Cancer Survival

Author:

Strobl Stephanie1,Korkmaz Belgin1,Devyatko Yelena1,Schuetz Michael1,Exner Ruth1,Dubsky Peter C.1,Jakesz Raimund1,Gnant Michael1

Affiliation:

1. Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria;

Abstract

Randomized trials have studied bisphosphonates in the adjuvant setting of early breast cancer to investigate their ability to prevent treatment-induced bone loss. Trial results have also suggested their potential to prevent disease recurrence and metastases. These trials are summarized in this review. A recent patient-level meta-analysis by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) finds convincing evidence that adjuvant antiresorptive treatments provide persistent benefits to breast cancer patients in low-estrogen situations and should be considered an important part of the treatment algorithm.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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