The Impact of the Gut Microbiome on Colorectal Cancer-Reference-Cited by-同舟云学术

The Impact of the Gut Microbiome on Colorectal Cancer

Published:2018-03-04 Issue:1 Volume:2 Page:229-249
ISSN:2472-3428
Container-title:Annual Review of Cancer Biology
language:en
Short-container-title:Annu. Rev. Cancer Biol.

Author:

Maisonneuve Charles¹,Irrazabal Thergiory¹,Martin Alberto¹,Girardin Stephen E.¹²,Philpott Dana J.¹

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;,

2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Abstract

Colorectal cancer (CRC) represents one of the leading causes of morbidity and cancer-related mortality in the world. While the etiology of CRC is believed to arise from genetic mutations, alterations in the gut microbiota composition also influence cancer incidence and progression. This review focuses on how gut microbiota and their relationship with the innate immune system link inflammation to genotoxicity and carcinogenesis.

Publisher

Annual Reviews

Subject

Cancer Research,Cell Biology,Oncology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-030617-050240

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