Reinventing Radiobiology in the Light of FLASH Radiotherapy

Author:

Limoli Charles L.1,Vozenin Marie-Catherine2

Affiliation:

1. Department of Radiation Oncology, University of California, Irvine, California, USA;

2. Laboratory of Radiation Oncology, Radiation Oncology Service and Oncology Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting treatment modality that holds the promise of expanding the therapeutic index for nearly any cancer. At the heart of this exciting technology comes the capability to ameliorate major normal tissue complications without compromising the efficacy of tumor killing. This combination of benefits has now been termed the FLASH effect and relies on an in vivo validation to rigorously demonstrate the absence of normal tissue toxicity. The FLASH effect occurs when the overall irradiation time is extremely short (<500 ms), and in this review we attempt to understand how FLASH-RT can kill tumors but spare normal tissues—likely the single most pressing question confronting the field today.

Publisher

Annual Reviews

Subject

Cancer Research,Cell Biology,Oncology

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