FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health-Reference-Cited by-同舟云学术

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health

Published:2019-08-21 Issue:1 Volume:39 Page:21-44
ISSN:0199-9885
Container-title:Annual Review of Nutrition
language:en
Short-container-title:Annu. Rev. Nutr.

Author:

Koletzko Berthold¹,Reischl Eva²,Tanjung Conny³,Gonzalez-Casanova Ines⁴,Ramakrishnan Usha⁴,Meldrum Suzanne⁵,Simmer Karen⁵,Heinrich Joachim⁶⁷,Demmelmair Hans¹

Affiliation:

1. Dr. von Hauner Children's Hospital, University of Munich Medical Center, Ludwig-Maximilians-Universität München, 80337 Munich, Germany;

2. Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München (German Research Center for Environmental Health), 85764 Neuherberg, Germany

3. Jakarta and Indonesian Medical Education and Research Institute, Hubert Pantai Indah Kapuk Hospital, Jakarta 14460, Indonesia

4. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA

5. Centre for Neonatal Research and Education, School of Medicine, University of Western Australia, Perth, Western Australia 6009, Australia

6. Institute and Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center (CPC) Munich, Ludwig-Maximilians-Universität München, 80337 Munich, Germany

7. Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia

Abstract

Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human blood and tissue. FADS variants have been associated with plasma lipid concentrations, risk of cardiovascular diseases, overweight, eczema, pregnancy outcomes, and cognitive function. Studies on variations in the FADS genecluster provided some of the first examples for marked gene–diet interactions in modulating complex phenotypes, such as eczema, asthma, and cognition. Genotype distribution differs markedly among ethnicities, apparently reflecting an evolutionary advantage of genotypes enabling active long-chain PUFA synthesis when the introduction of agriculture provided diets rich in linoleic acid but with little arachidonic and eicosapentaenoic acids. Discovering differential effects of PUFA supply that depend on variation of FADS genotypes could open new opportunities for developing precision nutrition strategies based either on an individual's genotype or on genotype distributions in specific populations.

Publisher

Annual Reviews

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-082018-124250

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