Nutritional Regulation of Intestinal Stem Cells

Author:

Alonso Salvador123,Yilmaz Ömer H.24

Affiliation:

1. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA;

2. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

3. Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA

4. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA

Abstract

Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases including cancer. Stem cells, the central mediators of tissue regeneration, integrate dietary and energy cues via nutrient-sensing pathways to maintain growth or respond to stress. We discuss emerging data on the effects of diet and nutrient-sensing pathways on intestinal stem cells, as well as their potential application in the development of regenerative and therapeutic interventions.

Publisher

Annual Reviews

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

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