Regeneration Genetics

Author:

Chen Chen-Hui1,Poss Kenneth D.23

Affiliation:

1. Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan;

2. Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA;

3. Regeneration Next, Duke University, Durham, North Carolina 27710, USA

Abstract

Understanding how and why animals regenerate complex tissues has the potential to transform regenerative medicine. Here we present an overview of genetic approaches that have recently been applied to dissect mechanisms of regeneration. We describe new advances that relate to central objectives of regeneration biologists researching different tissues and species, focusing mainly on vertebrates. These objectives include defining the cellular sources and key cell behaviors in regenerating tissue, elucidating molecular triggers and brakes for regeneration, and defining the earliest events that control the presence of these molecular factors.

Publisher

Annual Reviews

Subject

Genetics

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