Organoid Imaging: Seeing Development and Function

Author:

Keshara Rashmiparvathi1,Kim Yung Hae1,Grapin-Botton Anne1

Affiliation:

1. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;, ,

Abstract

Organoids are miniaturized and simplified versions of an organ produced in vitro from stem or progenitor cells. They are used as a model system consisting of multiple cell types forming an architecture relevant to the organ and carrying out the function of the organ. They are a useful tool to study development, homeostasis, regeneration, and disease. The imaging of organoids has become a pivotal method to visualize and understand their self-organization, symmetry breaking, growth, differentiation, and function. In this review, we discuss imaging methods, how to analyze these images, and challenges in organoid research.

Publisher

Annual Reviews

Subject

Cell Biology,Developmental Biology

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