Lessons from Interspecies Mammalian Chimeras

Author:

Suchy Fabian1,Nakauchi Hiromitsu12

Affiliation:

1. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305;

2. Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan

Abstract

As chimeras transform from beasts of Greek mythology into tools of contemporary bioscience, secrets of developmental biology and evolutionary divergence are being revealed. Recent advances in stem cell biology and interspecies chimerism have generated new models with extensive basic and translational applications, including generation of transplantable, patient-specific organs.

Publisher

Annual Reviews

Subject

Cell Biology,Developmental Biology

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