Cohesin: Its Roles and Mechanisms-Reference-Cited by-同舟云学术

Cohesin: Its Roles and Mechanisms

Published:2009-12-01 Issue:1 Volume:43 Page:525-558
ISSN:0066-4197
Container-title:Annual Review of Genetics
language:en
Short-container-title:Annu. Rev. Genet.

Author:

Nasmyth Kim¹,Haering Christian H.²

Affiliation:

1. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom;

2. European Molecular Biology Laboratory, 69115 Heidelberg, Germany;

Abstract

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

Publisher

Annual Reviews

Subject

Genetics

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-genet-102108-134233

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