The Coevolution of Placentation and Cancer

Author:

Wagner Günter P.1234,Kshitiz 5,Dighe Anasuya12,Levchenko Andre16

Affiliation:

1. Systems Biology Institute, Yale University, West Haven, Connecticut, USA;, ,

2. Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA

3. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut, USA

4. Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA

5. Department of Biomedical Engineering, University of Connecticut Health, Storrs, Connecticut, USA;

6. Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA

Abstract

Analogies between placentation, in particular the behavior of trophoblast cells, and cancer have been noted since the beginning of the twentieth century. To what degree these can be explained as a consequence of the evolution of placentation has been unclear. In this review, we conclude that many similarities between trophoblast and cancer cells are shared with other, phylogenetically older processes than placentation. The best candidates for cancer hallmarks that can be explained by the evolution of eutherian placenta are mechanisms of immune evasion. Another dimension of the maternal accommodation of the placenta with an impact on cancer malignancy is the evolution of endometrial invasibility. Species with lower degrees of placental invasion tend to have lower vulnerability to cancer malignancy. We finally identify several areas in which one could expect to see coevolutionary changes in placental and cancer biology but that, to our knowledge, have not been explored. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 10 is February 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Publisher

Annual Reviews

Subject

General Veterinary,Genetics,Animal Science and Zoology,Biotechnology

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