Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development-Reference-Cited by-同舟云学术

Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development

Published:2020-02-15 Issue:1 Volume:8 Page:247-267
ISSN:2165-8102
Container-title:Annual Review of Animal Biosciences
language:en
Short-container-title:Annu. Rev. Anim. Biosci.

Author:

Ghorbani Amir¹²,Ngunjiri John M.¹,Lee Chang-Won¹²

Affiliation:

1. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA;, ,

2. Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, USA

Abstract

The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described “incomplete” virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development.

Publisher

Annual Reviews

Subject

General Veterinary,Genetics,Animal Science and Zoology,Biotechnology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-animal-021419-083756

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice;Vaccines;2024-03-13

2. Diversity and Complexity of Internally Deleted Viral Genomes in Influenza A Virus Subpopulations with Enhanced Interferon-Inducing Phenotypes;Viruses;2023-10-17

3. Development of in ovo-compatible NS1-truncated live attenuated influenza vaccines by modulation of hemagglutinin cleavage and polymerase acidic X frameshifting sites;Vaccine;2023-03

4. Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review;Viruses;2022-12-12

5. Expanding Mouse-Adapted Yamagata-like Influenza B Viruses in Eggs Enhances In Vivo Lethality in BALB/c Mice;Viruses;2022-06-14