Neuroecology of Alcohol Preference in Drosophila

Abstract

In this review, we highlight sources of alcohols in nature, as well as the behavioral and ecological roles that these fermentation cues play in the short lifespan of Drosophila melanogaster. With a focus on neuroethology, we describe the olfactory detection of alcohol as well as ensuing neural signaling within the brain of the fly. We proceed to explain the plethora of behaviors related to alcohol, including attraction, feeding, and oviposition, as well as general effects on aggression and courtship. All of these behaviors are shaped by physiological state and social contexts. In a comparative perspective, we also discuss inter- and intraspecies differences related to alcohol tolerance and metabolism. Lastly, we provide corollaries with other dipteran and coleopteran insect species that also have olfactory systems attuned to ethanol detection and describe ecological and evolutionary directions for further studies of the natural history of alcohol and the fly.