Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries

Author:

Parrish Marcus C.12,Tan Yuan Jin13,Grimes Kevin V.12,Mochly-Rosen Daria12

Affiliation:

1. SPARK Translational Research Program, Stanford University School of Medicine, Stanford, California 94305, USA;

2. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA

3. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305, USA

Abstract

With pharmaceutical companies shrinking their research departments and exiting out of efforts related to unprofitable diseases, society has become increasingly dependent on academic institutions to perform drug discovery and early-stage translational research. Academic drug discovery and translational research programs assist in shepherding promising therapeutic opportunities through the so-called valley of death in the hope that a successful new drug will result in saved lives, improved health, economic growth, and financial return. We have interviewed directors of 16 such academic programs in the United States and found that these programs and the projects therein face numerous challenges in reaching the clinic, including limited funding, lack of know-how, and lack of a regional drug development ecosystem. If these issues can be addressed through novel industry partnerships, the revision of government policies, and expanded programs in translational education, more effective new therapies are more likely to reach patients in need.

Publisher

Annual Reviews

Subject

Pharmacology,Toxicology

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