A Contemporary Look at Biomechanical Models of Myocardium

Author:

Avazmohammadi Reza1,Soares João S.12,Li David S.1,Raut Samarth S.1,Gorman Robert C.3,Sacks Michael S.1

Affiliation:

1. James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, and Department of Biomedical Engineering, University of Texas, Austin, Texas 78712, USA;

2. Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USA

3. Gorman Cardiovascular Research Group, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Abstract

Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural observations, and specific test conditions to which they are fitted. We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium. We further explore the experimental and numerical techniques used to identify the model parameters. Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior. We conclude by pointing to future directions in the areas of optimal form as well as new approaches for constitutive modeling of myocardium.

Publisher

Annual Reviews

Subject

Biomedical Engineering,Medicine (miscellaneous)

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