Circulating Tumor Cells: Diagnostic and Therapeutic Applications

Author:

Lin Eric123,Cao Thong4,Nagrath Sunitha123,King Michael R.4

Affiliation:

1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA;

2. University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA

3. Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, USA

4. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA;

Abstract

Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. We discuss the advantages and limitations of such strategies and how they may lead to the development of the next generation of antimetastasis treatments.

Publisher

Annual Reviews

Subject

Biomedical Engineering,Medicine (miscellaneous)

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