The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits-Reference-Cited by-同舟云学术

The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits

Published:2003-09 Issue:1 Volume:4 Page:257-291
ISSN:1527-8204
Container-title:Annual Review of Genomics and Human Genetics
language:en
Short-container-title:Annu. Rev. Genom. Hum. Genet.

Author:

Florez Jose C.¹²³⁴⁵,Hirschhorn Joel¹²³⁴⁵,Altshuler David¹²³⁴⁵

Affiliation:

1. Diabetes Unit and Departments of Medicine and Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114,

2. Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114

3. Program in Medical and Population Genetics, Whitehead/MIT Center for Genome Research, Cambridge, Massachusetts 02139

4. Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts 02114

5. Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114

Abstract

Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic component. We review the division of diabetes into different subtypes based on clinical phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes, and the recent identification of several diabetes genes by large association studies. We use the lessons learned from this extensive body of evidence to illustrate general implications for the genetic analysis of complex traits.

Publisher

Annual Reviews

Subject

Genetics(clinical),Genetics,Molecular Biology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.4.070802.110436

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