New Therapeutics for Chronic Heart Failure

Author:

Mann Douglas L.123,Deswal Anita123,Bozkurt Biykem123,Torre-Amione Guillermo123

Affiliation:

1. Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, Texas 77030;

2. Houston Veterans Administration Medical Center, 2002 Holcombe Blvd., Houston, Texas 77030;

3. The Methodist Hospital, 6565 Fannin Street, Houston, Texas 77030

Abstract

▪ Abstract  Traditionally, clinicians have viewed heart failure either as a problem of excessive salt and water retention caused by abnormalities of renal blood flow, or as a hemodynamic problem associated with a reduced cardiac output and excessive peripheral vasoconstriction. Recently, clinicians have begun to adopt a neurohormonal model in which heart failure progresses because of the toxic effects of endogenous biological systems that become activated in heart failure. We review the rationale for existing heart failure therapies and discuss the reasoning behind the development of some emerging therapies.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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