Affiliation:
1. Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908;
2. Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143
Abstract
▪ Abstract Significant progress has been made in elucidating the mechanisms of viral membrane fusion proteins; both those that function at low, as well as those that function at neutral, pH. For many viral fusion proteins evidence now suggests that a triggered conformational change that exposes a previously cryptic fusion peptide, along with a rearrangement of the fusion protein oligomer, allows the fusion peptide to gain access to the target bilayer and thus initiate the fusion reaction. Although the topologically equivalent process of cell-cell fusion is less well understood, several cell surface proteins, including members of the newly described ADAM gene family, have emerged as candidate adhesion/fusion proteins.
Subject
Cell Biology,Developmental Biology
Cited by
520 articles.
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