The Formation of TGN-to-Plasma-Membrane Transport Carriers

Author:

Bard Frédéric1,Malhotra Vivek1

Affiliation:

1. Cell and Developmental Biology Department, University of California San Diego, La Jolla, California 92093;,

Abstract

In the trans-Golgi network (TGN), proteins are sorted for transport to the endosomes, plasma membrane, preceding Golgi cisternae, and endoplasmic reticulum. The formation of clathrin-coated vesicles for transport to the endosomes and of COP-I-coated vesicles for retrograde trafficking is fairly well characterized at the molecular level. We describe our current understanding of the TGN-to-cell-surface carriers, with a specific focus on the components involved in membrane fission. Inhibiting the fission machinery promotes growth of transport carriers into large tubules that remain attached to the TGN. Overactivating this machinery, on the other hand, vesiculates the TGN. To understand how membrane fission is regulated by cargo to form transport carriers yet prevents complete vesiculation of the TGN remains a daunting challenge. We discuss these issues with regard to TGN-to-cell-surface transport carriers.

Publisher

Annual Reviews

Subject

Cell Biology,Developmental Biology

Cited by 179 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3