INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS-Reference-Cited by-同舟云学术

INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS

Published:1998-11 Issue:1 Volume:14 Page:459-485
ISSN:1081-0706
Container-title:Annual Review of Cell and Developmental Biology
language:en
Short-container-title:Annu. Rev. Cell Dev. Biol.

Author:

Chapman Rowan¹,Sidrauski Carmela¹,Walter Peter¹

Affiliation:

1. Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0448;

Abstract

▪ Abstract Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR). Recent work has shown that this signaling pathway utilizes several novel mechanisms, including translational attenuation and a regulated mRNA splicing step. In this review we aim to integrate these recent advances with current knowledge about maintenance of ER composition and abundance.

Publisher

Annual Reviews

Subject

Cell Biology,Developmental Biology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.cellbio.14.1.459

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