MicroRNAs in Cancer-Reference-Cited by-同舟云学术

MicroRNAs in Cancer

Published:2009-02-01 Issue:1 Volume:60 Page:167-179
ISSN:0066-4219
Container-title:Annual Review of Medicine
language:en
Short-container-title:Annu. Rev. Med.

Author:

Garzon Ramiro¹,Calin George A.²,Croce Carlo M.³

Affiliation:

1. Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210

2. Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, Texas 77020

3. Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210;

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.med.59.053006.104707

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