Bisphosphonate-Related Osteonecrosis of the Jaw: Diagnosis, Prevention, and Management

Author:

Ruggiero Salvatore L.1,Mehrotra Bhoomi2

Affiliation:

1. New York Center for Orthognathic and Maxillofacial Surgery, Lake Success, New York 11042; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, State University of New York, Stony Brook, New York 11794; Division of Oral and Maxillofacial Surgery, Long Island Jewish Medical Center, New Hyde Park, New York 11040;

2. Division of Hematology/Oncology, Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York, 11040;

Abstract

Bisphosphonate therapy has been considered standard therapy in the management and care of cancer patients with metastatic bone disease and patients with osteoporosis. The efficacy of these drugs is due to their ability to inhibit osteoclast-mediated bone resorption. However, the postmarketing experience with intravenous and, to a much lesser extent, oral bisphosphonates has raised concerns about potential side effects related to profound bone remodeling inhibition and osteonecrosis isolated to the jaws. We review the risk factors, incidence, pathogenesis, prevention strategies, and management of this new complication.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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