RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

Author:

Geppert Martin1,Südhof Thomas C.2

Affiliation:

1. Abteilung Molekulare Neurobiologie, Max-Planck-Institut für experimentelle Medizin, Göttingen, 37075 Germany

2. Howard Hughes Medical Institute and Department of Molecular Genetics, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75235

Abstract

▪ Abstract  Synaptic vesicle exocytosis occurs in consecutive steps: docking, which specifically attaches vesicles to the active zone; priming, which makes the vesicles competent for Ca2+-triggered release and may involve a partial fusion reaction; and the final Ca2+-regulated step that completes fusion. Recent evidence suggests that the critical regulation of the last step in the reaction is mediated by two proteins with opposite actions: synaptotagmin, a Ca2+-binding protein that is essential for Ca2+-triggered release and probably serves as the Ca2+-sensor in fusion, and rab3, which limits the number of vesicles that can be fused as a function of Ca2+ in order to allow a temporally limited, repeatable signal.

Publisher

Annual Reviews

Subject

General Neuroscience

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