A NEW APPROACH TO DECODING LIFE: Systems Biology-Reference-Cited by-同舟云学术

A NEW APPROACH TO DECODING LIFE: Systems Biology

Published:2001-09 Issue:1 Volume:2 Page:343-372
ISSN:1527-8204
Container-title:Annual Review of Genomics and Human Genetics
language:en
Short-container-title:Annu. Rev. Genom. Hum. Genet.

Author:

Ideker Trey¹²³⁴⁵,Galitski Timothy¹²³⁴⁵,Hood Leroy¹²³⁴⁵

Affiliation:

1. Institute for Systems Biology1, Seattle, Washington 98105;

2. Departments of Molecular Biotechnology2, University of Washington, Seattle, Washington 98195;

3. Departments of Immunology3, University of Washington, Seattle, Washington 98195;

4. Departments of Bioengineering4, University of Washington, Seattle, Washington 98195;

5. Departments of Computer Science and Engineering5, University of Washington, Seattle, Washington 98195;

Abstract

▪ Abstract Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

Publisher

Annual Reviews

Subject

Genetics (clinical),Genetics,Molecular Biology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.2.1.343

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