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Imaging Transgenic Animals

Published:1999-08 Issue:1 Volume:1 Page:611-648
ISSN:1523-9829
Container-title:Annual Review of Biomedical Engineering
language:en
Short-container-title:Annu. Rev. Biomed. Eng.

Author:

Budinger T. F.¹²³,Benaron D. A.¹²³,Koretsky A. P.¹²³

Affiliation:

1. Department of Bioengineering and Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720;

2. Hansen Experimental Physics Laboratory (HEPL), Department of Physics, Stanford University, Stanford, CA 94305;

3. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213

Abstract

▪ Abstract Transgenic and eugenic animals as small as 30 g can be studied noninvasively by radionuclides with resolutions of 1–2 mm, by MRI with resolution of 100 μm and by light fluorescence and bioluminescence with high sensitivities. The technologies of radionuclide emission, magnetic resonance imaging, magnetic resonance spectroscopy, optical tomography, optical fluorescence and optical bioluminescence are currently being applied to small-animal studies. These technologies and examples of their applications are reviewed in this chapter.

Publisher

Annual Reviews

Subject

Biomedical Engineering,Medicine (miscellaneous)

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.bioeng.1.1.611

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