ELECTRICAL AND CALCIUM SIGNALING IN DENDRITES OF HIPPOCAMPAL PYRAMIDAL NEURONS

Author:

Magee Jeffrey123,Hoffman Dax123,Colbert Costa123,Johnston Daniel123

Affiliation:

1. Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112;

2. Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030;

3. Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204;

Abstract

▪ Abstract  This review discusses recent data regarding the different types of voltage-gated Na+, Ca2+, and K+ channels in dendrites of CA1 pyramidal neurons and their function for synaptic integration and plasticity. Na+ and Ca2+ channels are uniformly distributed throughout the dendrites, although Na+ channels in the soma and proximal dendrites differ in their inactivation properties from Na+ channels in more distal regions. Also, different regions of the neuron express different subtypes of Ca2+ channels. K+ channels are unevenly distributed, with the distal dendrites expressing a more than fivefold greater density of a transient A-type K+ channel than proximal regions. These K+ channels exert profound control over the excitability of the pyramidal neurons and the spread of synaptic potentials throughout the dendrites. The ways in which the active properties of dendrites may contribute toward the induction and maintenance of long-term synaptic plasticity are discussed.

Publisher

Annual Reviews

Subject

Physiology

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