MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING-Reference-Cited by-同舟云学术

MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

Published:1997-06 Issue:1 Volume:26 Page:259-288
ISSN:1056-8700
Container-title:Annual Review of Biophysics and Biomolecular Structure
language:en
Short-container-title:Annu. Rev. Biophys. Biomol. Struct.

Author:

Kuriyan John¹²,Cowburn David¹²

Affiliation:

1. Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021

2. The Rockefeller University, 1230 York Avenue, New York, NY 10021

Abstract

▪ Abstract A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

Publisher

Annual Reviews

Subject

Structural Biology,Biophysics

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.biophys.26.1.259

Cited by 516 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of a novel representation of drug 3D structures and enhancement of the TSR-based method for probing drug and target interactions;Computational Biology and Chemistry;2024-10

2. Massively parallel measurement of protein–protein interactions by sequencing using MP3-seq;Nature Chemical Biology;2024-08-27

3. Role of non-receptor tyrosine kinases in epilepsy: significance and potential as therapeutic targets;Expert Opinion on Therapeutic Targets;2024-04-02

4. Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK);Bioorganic & Medicinal Chemistry;2023-12

5. Characterization of Fusarium verticillioides Med1 LxxLL Motif Involved in Fumonisin Biosynthesis;Toxins;2023-11-13