Affiliation:
1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England
2. Laboratory of Molecular Biophysics, Oxford Centre for Molecular Sciences, South Parks Road, Oxford OX1 3QU, England
Abstract
Considerable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and molecular models of their adhesion complexes. For neural cell adhesion molecules, L1, fibronectin, tenascin-C, integrins, and vascular cell adhesion molecules, the molecular structure of domains, and in most cases their binding sites, have been elucidated. The substrate recognition sites in some of these molecules possess rate constants for association and dissociation that permit both rapid cell migration and, through avidity, high-affinity cell-cell interactions.
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296 articles.
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