Cell Culture Models in Microfluidic Systems

Author:

Meyvantsson Ivar1,Beebe David J.2

Affiliation:

1. Bellbrook Labs, LLC, Madison, Wisconsin 53711;

2. Department of Biomedical Engineering, University of Wisconsin at Madison, Madison, Wisconsin 53706;

Abstract

Microfluidic technology holds great promise for the creation of advanced cell culture models. In this review, we discuss the characterization of cell culture in microfluidic systems, describe important biochemical and physical features of the cell microenvironment, and review studies of microfluidic cell manipulation in the context of these features. Finally, we consider the integration of analytical elements, ways to achieve high throughput, and the design constraints imposed by cell biology applications.

Publisher

Annual Reviews

Subject

Analytical Chemistry

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