APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging-Reference-Cited by-同舟云学术

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Published:2009-04-01 Issue:1 Volume:5 Page:343-362
ISSN:1548-5943
Container-title:Annual Review of Clinical Psychology
language:en
Short-container-title:Annu. Rev. Clin. Psychol.

Author:

Bookheimer Susan¹²,Burggren Alison¹

Affiliation:

1. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Department of Psychology, University of California, Los Angeles, California 90095;

2. Department of Psychology, University of California, Los Angeles, California 90095;

Abstract

Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients experience evidence of cognitive decline. Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological features as AD, and some appear to be predictive of future cognitive decline. This review examines the most recent data on brain changes in genetic risk for AD and discusses the benefits and potential risks of detecting individuals at risk.

Publisher

Annual Reviews

Subject

Psychiatry and Mental health,Clinical Psychology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.clinpsy.032408.153625

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